Santa Cruz del Quiché is a city, with a population of 78,279, in Guatemala. It serves as the capital of the El Quiché department and the municipal seat of Santa Cruz del Quiché municipality. The city is located at 15.03°N 91.15°W, at an elevation of 2,021 m above sea level. It has an airport, Quiché Airport, located just south of the city.